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In another study, Rametti and colleagues used diffusion tensor imaging DTI to compare 18 androphilic male-to-female transsexuals with 19 gynephilic males and 19 androphilic cisgender females. Scientists speculate that the definition of masculine characteristics during puberty and the increased social status afforded to men are two possible motivations for a female-to-male transition. Both groups experienced amygdala activation in response to EST. A study compared male-to-female transsexuals both androphilic and gynephilic , mostly already undergoing hormone treatment, with cisgender male controls. Hulshoff Pol et al. Identity Concordance, Transition, Rearing, and Orientation".


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Sexual Differentiation of Our Brains. A diffusion tensor imaging study". American Academy of Pediatrics. The androphilic transsexuals differed from both control groups in multiple brain areas, including the superior longitudinal fasciculus, the right anterior cingulum, the right forceps minor, and the right corticospinal tract. Transsexual people have a gender identity that does not match their assigned sex , often resulting in gender dysphoria. A variant genotype for a gene called CYP17 , which acts on the sex hormones pregnenolone and progesterone , has been found to be linked to female-to-male transsexuality but not MtF transsexuality. Ray Blanchard developed a taxonomy of male-to-female transsexualism that proposes two distinct etiologies for androphilic and gynephilic individuals that has become highly controversial, supported by J.


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Researchers of the Karolinska Institute of Stockholm used MRI to compare 24 gynephilic male-to-female transsexuals with 24 cisgender male and 24 cisgender female controls. Webarchive template wayback links Wikipedia articles needing page number citations from October Articles with incomplete citations from October All articles with incomplete citations Wikipedia articles needing page number citations from November A study compared male-to-female transsexuals both androphilic and gynephilic , mostly already undergoing hormone treatment, with cisgender male controls. Scientists speculate that the definition of masculine characteristics during puberty and the increased social status afforded to men are two possible motivations for a female-to-male transition. Transsexual people have a gender identity that does not match their assigned sex , often resulting in gender dysphoria.


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